Zoology Research Laboratory

Zoology Research Laboratory

The Zoology Reserach Laboratory hosts the “Computational Structural Biology and Drug Discovery” research group, who conduct research on; human, parasitic, bacterial and viral proteins.

One of our group’s predominantly studied areas of research is; computational structural biology and structure-based drug design. In line with this objective; gene cloning, recombinant protein production (in E. coli. expression systems), robust and clean purification by affinity chromatograpy and certain biochemical and biophysical analyses of target proteins take place in our laboratory. Structural modelling, high-througput virtual screening, molecular docking and molecular dynamics simulations of druggable proteins also take place with the aim of revealing compounds that are potent inhibitor candidates. Additionally, the design and in vitro validation of anti-cancer and anti-microbial peptides are also among the drug studies performed.

Another valuable research purpose for the team consists of our work aimed at a greater general understanding of the structural biology and molecular evolution of poly-extremophilic proteins.

Team:

Associate Professor Özal MUTLU (Department Head)

Esra ALBAYRAK (PhD Candidate): Anticancer and antimicrobial peptide discovery, computational structural biology, structural biology of realistic cancer cell membranes.

S Merve BOSTANCIOĞLU (PhD Candidate): Antiprotozoal drug discovery, computational structural biology.

Can AYGÜN (PhD Candidate): Antimicrobial drug discovery, computational structural biology.

Sude BÜYÜKKURT (MSc Student.): Antimicrobial peptide discovery, computational structural biology, structural biology of bacterial membranes.

Sura Sanem KÖSE (MSc Student): Structural biology and evolution of poly-extremophilic proteins.

 

Associates:

Prof. Dilek TURGUT-BALIK (Yildiz Technical University-Department of Bioengineering)

Prof. Nagihan GÜLSOY (Marmara University-Department of Biology)

Prof. Safiye ERDEM (Marmara University-Chemistry Department)

Prof. Ayşe OGAN (Marmara University-Chemistry Department)

Prof. Özkan GÜLSOY (Marmara University-Department of Metallurgical and Materials Engineering)

Prof. Hiqmet KAMBERAJ (International Balkan University-Department of Computer Engineering / North Macedonia)

Prof. Özkan DANIŞ (Marmara University-Chemistry Department)

Assoc. Prof. Soner ÇUBUK (Marmara University- Chemistry Department)

Assoc. Prof. Serap DERMAN (YTU-Department of Bioengineering)

Asst. Prof. Sinem KOÇER (Yeni Yüzyil University-Faculty of Pharmacy)

Asst. Prof. Emrah SARIYER (Artvin Çoruh University)


This page updated by Biology on 07.06.2022 09:42:34

QUICK MENU